Treatment of spasticity associated with multiple sclerosis or with spinal cord injury or disease.
Posology and Method of Administration:
For oral use.
It is usual to start with a single dose of 2mg increasing by 2mg increments at no less than half-weekly intervals. The optimum therapeutic response is generally achieved with a daily dose of between 12 and 24mg, administered in 3 or 4 equally spaced doses. Single doses should not exceed 12mg. The total daily dose should not exceed 36mg.
- The use of tizanidine in patients with significantly impaired hepatic function is contraindicated, because tizanidine is extensively metabolised by the liver.
- Concomitant use of tizanidine with strong inhibitors of CYP1A2 such as fluvoxamine or ciprofloxacin is contraindicated
- Hypersensitivity to tizanidine or to any of the excipients.
The most common side effects are somnolence, dizziness, bradycardia, tachycardia, hypotension, rebound hypertension, dry mouth, nausea, gastrointestinal disturbances, fatigue, and Blood pressure decrease.